Serevent nationwide surveillance study: comparison ofsalmeterol with salbutamol in asthmatic patients
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منابع مشابه
Serevent nationwide surveillance study: comparison of salmeterol with salbutamol in asthmatic patients who require regular bronchodilator treatment.
OBJECTIVE To compare safety of salmeterol and salbutamol in treating asthma. DESIGN Double blind, randomised clinical trial in parallel groups over 16 weeks. SETTING General practices throughout the United Kingdom. SUBJECTS 25,180 patients with asthma considered to require regular treatment with bronchodilators who were recruited by their general practitioner (n = 3516). INTERVENTIONS S...
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Salmeterol is a new inhaled 2 adrenoceptor agonist, which has been shown in animal experiments to produce a more prolonged bronchodilator effect than currently available f2 adrenoceptor agonists. It was studied in eight adult asthmatic patients. Each patient received on separate test days salbutamol 200 pg and salmeterol 50, 100, and 200 pg according to a randomised, double blind, crossover des...
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A randomized, double-blind, crossover trial was designed to compare the acute effects of Combivent and salbutamol on spirometric parameters in patients with moderate to severe asthma. Nineteen patients with a mean baseline forced expiratory volume in 1 sec. (FEV]) less than 65% predicted, were randomized on two separate days to receive two puffs of salbutamol (200 µg) or two puffs of Combiv...
متن کاملEffect of acute hyperoxia on the bronchodilator response to salbutamol in stable asthmatic patients.
BACKGROUND Recent animal studies have suggested that changes in oxygen tension may alter airway responses to bronchoconstrictor and bronchodilator stimuli. These effects may have relevance to the management of acute exacerbations of asthma but have not been well studied in man. This study was designed therefore to examine the effect of acute hyperoxia (Fio2 1.0) on the bronchodilator response t...
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The effect of 5 mg nebulised salbutamol on the cardiorespiratory responses to a progressive maximal exercise test was investigated in eight asthmatic (mean forced expiratory volume in one second (FEV1) 3.48 (1.0) litres) and eight non-asthmatic men. Exercise tests were performed on a bicycle ergometer after administration of nebulised salbutamol or matched saline placebo. In the asthmatic subje...
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تاریخ انتشار 2006